Writing in the journal Paediatric Diabetes, the authors describe training and supporting the family to prepare the diluted insulin and insert it into the pump.
Lead author and consultant in paediatric diabetes at Cambridge University Hospital (CUH), Dr Rachel Williams, said: “The artificial pancreas takes over a proportion of the daily management of the illness, although there is a still a huge burden of care for carers of very young children with diabetes even when using the most up to date technology.
By using diluted insulin, we can control blood glucose levels in a much more subtle way – avoiding highs and lows which could cause developmental problems for such a young child.
— Dr Rachel Williams
“Although the artificial pancreas is currently only licensed down to one year old, we discussed all options with the family, and decided to use the closed-loop system off license. It has worked really well, and thanks to the collaboration with diabetes teams in Norwich we have been able to support this family to use it successfully.”
Dr Emma Webb, paediatric endocrinologist at Norfolk and Norwich University Hospital (NNUH), and co-author, said: “The diabetes team at NNUH has significant experience of managing children on pump therapy. However, the concept of managing a 6-month-old on a novel closed loop system was daunting.
“Working in collaboration with the CUH team to look after Millie has been a fantastic way for us to safely deliver her care closer to home. The embedding of video consultations into the NHS infrastructure as a result of the COVID-19 pandemic also helped us to learn and to deliver her care as a unified team across both sites.”
The management of very small children with type 1 diabetes is notoriously challenging and can be very difficult to achieve adequate glucose control without unacceptable rates of hypoglycaemia.
The artificial pancreas is very effective in moderating blood glucose levels. It consists of an app, known as CamAPS FX, which works with an insulin pump and a glucose monitor to automatically deliver insulin when needed.
It also uploads the data to a website so that medical teams can see real-time information about the patient’s condition. This makes it much easier to provide health advice remotely.
Dr Williams emphasised the importance of a multi-disciplinary team in looking after children with diabetes, adding: “I can’t stress enough how delivery of care would be impossible without the expertise of a team of dedicated professionals including administrative staff, dieticians, doctors, nurses, pharmacists, play specialists and psychologists.”